"The game crashes on launch."
The most robust, actively maintained solution to add mouse support to Resident Evil 4 (Steam version) is the mod. This mod fixes not only the mouse support but also camera issues, FPS caps, and more. Steps to Download and Install
Combine this mouse fix with the RE4 HD Project (by Albert Marin and Cris Morales). It replaces all textures with 4K hand-crafted versions. The download is large (~30GB) but transforms the game into a modern remaster.
There were glitches, too. An option menu that hid the sensitivity sliders behind a half-worded tooltip, a cursor that momentarily drifted like a lost bird when she tabbed out to check a message. She cursed politely at the UI and adjusted the DPI on her mouse, searching for the sweet spot between twitch and sluggishness. When she found it, the game changed again—no miracles, only small, important differences. It was the same old world, rendered with new patience. Download Resident Evil 4 Pc Mouse Support
No legitimate mouse support mod requires you to disable all antivirus protection permanently.
Corrects off-center camera bugs when zooming with a mouse.
Allows you to pull the camera back for better visibility. How to Download and Setup re4_tweaks "The game crashes on launch
: Search for REFramework for Resident Evil 4 Remake. How to Install: Download the REFramework zip file.
This version has mouse support, but it is notoriously clunky without mods.
Method 2: MouseFix by Albert Marin (Best for Ultimate HD Edition) It replaces all textures with 4K hand-crafted versions
Extract dinput8.dll , dinput8.ini , and the re4_tweaks folder into your game's directory (typically Steam\steamapps\common\Resident Evil 4\Bin32 ).
For this specific version, you must download a third-party tool like finaly's MouseAim Patch .